A Chromatographic Impurity Signature Profile Analysis for Cocaine Using Capillary Gas Chromatography
Casale, JF
Senior research chemist and forensic chemist, respectively, Drug Chemistry Laboratory, State Bureau of Investigation, Raleigh, NC.

Waggoner Jr, RW
Senior research chemist and forensic chemist, respectively, Drug Chemistry Laboratory, State Bureau of Investigation, Raleigh, NC.


Abstract
The signature patterns of cocaine samples were examined by capillary gas chromatography using 14 impurities commonly found in illicit cocaine samples. The procedure is based on acidic, basic, and neutral impurities introduced from the coca plant and from the processing of cocaine in clandestine laboratories. Impurities containing either alcoholic, N-nor, or carboxylic acid functional groups were analyzed as their silyl derivatives. The reported procedure provides a simple one-step assay for obtaining chromatographic impurity signature profile analyses (CISPA) of illicit cocaine samples using flame ionization detection (FID).

Keywords:
chromatographic analyses, chromatographic analysis, CISPA, cocaine, cocaine impurities, forensic science, gas chromatography, signature profile, toxicology

Paper ID: JFS365911312

ASTM International is a member of CrossRef.
Author Casale JF, Waggoner RW, Jr Title A Chromatographic Impurity Signature Profile Analysis for Cocaine Using Capillary Gas Chromatography Symposium , Committee on