Solid-Phase Extraction, Identification, and Quantitation of 11-Nor-Delta-9-Tetrahydrocannabinol-9-Carboxylic Acid
Nakamura, GR
Chief chemist and forensic chemists, respectively, U.S. Army Criminal Investigation Laboratory-Pacific. APO San Francisco, CA.

Meeks, RD
Chief chemist and forensic chemists, respectively, U.S. Army Criminal Investigation Laboratory-Pacific. APO San Francisco, CA.

Stall, WJ
Chief chemist and forensic chemists, respectively, U.S. Army Criminal Investigation Laboratory-Pacific. APO San Francisco, CA.


Abstract
A procedure has been developed to extract and recover minute amounts of delta-9-carboxytetrahydrocannabinol (THC-COOH) from urine. A new non-isotopic internal standard is introduced to permit a chromatographic assay of the metabolite. The method affords a 91% recovery of 20 ng/mL of the THC-COOH acid from spiked urine with the assurance of a 3.8% coefficient of variation.

Keywords:
chromatographic analysis, forensic science, tetrahydrocannabinol, toxicology

Paper ID: JFS354900792

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Author Nakamura GR, Meeks RD, Stall WJ Title Solid-Phase Extraction, Identification, and Quantitation of 11-Nor-Delta-9-Tetrahydrocannabinol-9-Carboxylic Acid Symposium , Committee on