Behavior of Genetic Markers in Recipients After Bone Marrow Transplantation and Problems in Forensic Medicine
Ikemoto, S
Professor and immunohematologists, respectively, Department of Legal Medicine and HumanGenetics, Jichi Medical School, Tochigi, Japan.

Kajii, E
Professor and immunohematologists, respectively, Department of Legal Medicine and HumanGenetics, Jichi Medical School, Tochigi, Japan.

Tsuchida, S
Professor and immunohematologists, respectively, Department of Legal Medicine and HumanGenetics, Jichi Medical School, Tochigi, Japan.

Amemiya, Y
Associate professor and professor, respectively, Department of Haematology, Jichi MedicalSchool, Tochigi, Japan.

Kato, K
Vice director, Tottori Central Hospital, Tottori, Japan.

Miura, Y
Associate professor and professor, respectively, Department of Haematology, Jichi MedicalSchool, Tochigi, Japan.


Abstract
The authors report studies on four pairs of donors and recipients in bone marrow transplantation (BMT). A broad range of gene markers at 41 gene loci, including 11 red blood cell markers, 5 human lymphocyte antigen (HLA) types, 12 serum protein markers, 5 red cell enzyme markers, and 8 salivary markers were evaluated before and after BMT over 2 months. As a result, 9 out of 41 gene loci of genetic markers in recipients were transformed into the donor type. BMT between family members may lead to transformation of gene markers, but within a pattern compatible with family inheritance patterns, and no genetic paradox will be found in later surveys of familial genetic relationships. However, in a personal identification system in forensic medicine using genetic markers as an index, the appearance of a phenotype incompatible with a blood relationship is possible after BMT with a non-blood-relative donor. This result is similar to the inheritance pattern observed after artificial insemination by a donor's semen (AID), a more complete out-of-family cross.

Keywords:
bone marrow transplantation, changes in genetic markers, forensic medicine, forensic science, genetic typing, pathology and biology

Paper ID: JFS353900548

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Author Ikemoto S, Kajii E, Tsuchida S, Amemiya Y, Kato K, Miura Y Title Behavior of Genetic Markers in Recipients After Bone Marrow Transplantation and Problems in Forensic Medicine Symposium , Committee on